P.I. Responsible: Francisco Domínguez, PhD
Other Researchers: Hortensia Ferrero
Technician: Alicia Quiñonero
Endometriosis is one of the most frequent bening gynecological diseases in women, which may cause infertility. For this reason, many women have to drawn on assisted reproductive techniques. Furthermore, these women have to be treated with one of the few available hormonal or surgery options. Many studies have shown low implantation rates in endometriosis patients when using embryos of ovarian endometriosis patients (Garrido et al, 2002; Simón, et al, 1994; Pellicer, et al, 1994)., suggesting the direct relation of the ovarian endometriosis and the low quality of these embryos. Endometriosis is an estrogen-dependent inflammatory condition (Vercellini P, et al., 2014), so it is possible that a paracrine effect could alter the quality of the embryos, decreasing the chance to implant of these embryos. Thus, our hypothesis is that a different expression pattern exists between embryos coming from ovarian endometriosis and healthy women. To check our hypothesis we will study the transcription expression profile of these embryos using next sequencing generation (NGS). From the data obtained from these embryos we will develop a new diagnostic method that allows the personalized treatment of the patient, deciding if the IVF patient has high or low chances of pregnancy or giving the patients the opportunity to enroll in a ovodonation program from the beginning.