Proteimics Endometrial
Proteimics Endometrial

(Francisco Dominguez Ph.D)

Currently, to evaluate the state of the endometrium of a woman there are a few techniques with little objective like the histological appraisal...

Testicular stem cells
Testicular stem cells

(Carlos Simón MD, PhD)

Sperm generated in the adult male gonads from a small germinal stem cell population..

Endometrial and myometrial stem cells
Endometrial and myometrial stem cells

 (Irene Cervelló Alcaraz, PhD)

The exceptional capacity of human endometrial tissue regeneration, that is renewed monthly and that can do it during all the life...

Endometrial receptivity
Endometrial receptivity

(Felipe Vilella, PhD)

The endometrium is the surface tissue that cover the walls of the uterus. In humans, this tissue suffers physiological and morphological modifications along the menstrual cycle...

Endometriosis
Endometriosis

(Francisco Domínguez PhD)

Endometriosis is one of the most frequent bening gynecological diseases in women, which may cause infertility.

Ovarian hiperstimulation
Ovarian hiperstimulation

(Antonio Pellicer Martínez MD, PhD)

During assisted reproduction cycles and in order to obtain a higher number of oocytes women are administered Gonadotrophins....

Embryonic viability
Embryonic viability

 (Francisco Dominguez, PhD)

Nowadays the unique method used to select the most viable embryo with the greatest potential in IVF implantation ...

 

Reprograming
Reprograming

 (José V. Medrano, PhD)

Infertility affects up to 15% of couples in reproductive age in Europe. Among the different diseases that can lead to infertility

Vitamine D treatment on the uterine fibroids growth
Vitamine D treatment on the uterine fibroids growth

 Uterine fibroids are the most common benign tumor in women of reproductive age, affecting 25% of them...

Endometrial Database
Endometrial Database

Universidad de Valencia

EDB is a service of Fundacion IVI, sponsored by University of Valencia (SPAIN)


Endometriosis

Investigador

P.I. Responsible: Francisco Domínguez, PhD
Other Researchers: Hortensia Ferrero
Technician: Alicia Quiñonero





Investigation description

Endometriosis is one of the most frequent bening gynecological diseases in women, which may cause infertility. For this reason, many women have to drawn on assisted reproductive techniques.  Furthermore, these women have to be treated with one of the few available hormonal or surgery options. Many studies have shown low implantation rates in endometriosis patients when using embryos of ovarian endometriosis patients (Garrido et al, 2002; Simón, et al, 1994; Pellicer, et al, 1994)., suggesting the direct relation of the ovarian endometriosis and the low quality of these embryos.  Endometriosis is an estrogen-dependent inflammatory condition (Vercellini P, et al., 2014), so it is possible that a paracrine effect could alter the quality of the embryos, decreasing the chance to implant of these embryos. Thus, our hypothesis is that a different expression pattern exists between embryos coming from ovarian endometriosis and healthy women. To check our hypothesis we will study the transcription expression profile of these embryos using next sequencing generation (NGS). From the data obtained from these embryos we will develop a new diagnostic method that allows the personalized treatment of the patient, deciding if the IVF patient has high or low chances of pregnancy or giving the patients the opportunity to enroll in a ovodonation program from the beginning.